OUR TECHNOLOGY

The Green Bull Institute is a scientific research center dedicated to the development of advanced technologies for the extraction, analysis and standardization of plant extracts with special emphasis on cannabinoids, terpenes and other bioactive compounds. 

Green Bull
Institute for Advanced Botanical Research

Our
goal

Our goal is to connect science and industry through innovative approaches that enable the application of natural ingredients in the pharmaceutical, cosmetic and food industries.

Our
mission

Through a multidisciplinary team of scientists and engineers, the Institute researches and develops sustainable and highly efficient extraction processes, advanced analysis methods and new formulations of natural products.

Our
focus

Our focus is on scientifically based results, transparency and the highest quality standards.

Our Science Team

Our research team consists of PhDs, chemists, biotechnologists and industrial application experts with many years of experience in the fields of phytochemistry, pharmaceutical technology and product development.

Research Departments

1. Phytochemistry and extraction technologies

We develop and optimize the processes of supercritical CO₂ extraction, ethanol extraction and fractionation of bioactive compounds. All processes are carried out in a closed cycle, according to internal SOPs (Standard Operating Procedures), with full control of temperature, pressure and media purity.

2. Analytical chemistry and quality control

We use validated HPLC, GC-MS, FTIR and UV-VIS methods for the identification and quantification of cannabinoids, terpenes and flavonoids. Our protocols ensure high reproducibility and reliability of results in accordance with international standards.

3. Applied research and formulation

In cooperation with industrial partners, we develop innovative formulations for cosmetic, pharmaceutical and nutraceutical applications, based on scientifically verified extracts. Our equipment and infrastructure Green Bull Institute operates in a facility with an area of ​​2,000 m², located at Kurtovići 17, Klis (Croatia). The facility contains a modernly equipped laboratory, a pilot plant for extraction and distillation, and a dedicated space for formulation development and quality control.

The institute has the most modern systems for the extraction and processing of plant materials:

  • 3× Apeks Supercritical “The Force” (120 L CO₂ extraction units)
  • Capna ATLES Ethanol Extraction Line (30 kg batch)
  • ARES Short-Path Distillation Units
  • YHCHEM JGR-200 L reactors with precise temperature control
  • Filtration, winterization and decarboxylation systems
  • Analytical support: HPLC, GC-MS, UV-VIS and FTIR (in collaboration with partner laboratories)

All processes are carried out in a closed cycle, with automated control of parameters and complete media recirculation, which ensures safety, reproducibility and environmental sustainability.

Projects and research

Current projects

  • Standardization of extracts for cosmetic and pharmaceutical use
  • Stability of cannabinoids in different solvents and formulations
  • Terpene profile analysis using GC-MS and NMR spectroscopy
  • Development of biologically active formulations with immortelle, lavender and rosemary extracts
  • Evaluation of the synergistic effects of cannabinoids and terpenes in topical preparations

 

Ethical and regulatory framework

All processes are carried out in accordance with the principles:
– GMP (Good Manufacturing Practice)
– GLP (Good Laboratory Practice)
– ISO 9001 and ISO 14001 guidelines
– EU regulation on cosmetic, food and pharmaceutical products

The Institute operates within the legal framework of the Republic of Croatia and the European Union, and all products and protocols undergo internal and external quality control. The Institute, in cooperation with the certification body Quality Austria, is in the process of implementing a quality management system according to ISO 9001:2015, ISO 14001:2015 and HACCP standards for safety and process control in the production and handling of herbal extracts. The goal is to establish an integrated system that ensures full traceability, safety and compliance with EU regulations.

Our Products

✨ COSMETIC-GRADE BROAD-SPECTRUM CBD OIL (THC ND) ✨

– CBD isolate over 99% pure
– Terpene profile according to client's wishes
– EU origin, tested and certified

In addition to standard research and development activities, Green Bull Institute offers high-quality phytochemical products for industrial applications, including CBD isolates, broad-spectrum oils and natural terpene fractions.

Cooperation and contact
Are you interested in collaborating with our research team?
Send a project proposal, sample for analysis, or partnership inquiry to:

📧 institute@greenbull.hr
📍 Kurtovići 17, 21231 Klis, Hrvatska